Low acidic species compositions and methods for producing and using the same

US9266949B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Natarajan Ramasubramanyan · Westborough, US
• Lihua Yang · Nanhu, CN
• Matthew Omon Herigstad · Boston, US
• Hong Yang · Atlanta, US
• Kartik Subramanian · Northborough, US
• Xiaobei Zeng · Carolina, US
• Diane D. Dong · Shrewsbury, US
• Wen Chung Lim · Worcester, US
• Kathreen A. Gifford · Marlborough, US
• Zehra Kaymakcalan · Westborough, US
• Christopher Chumsae · North Andover, US

Key dates

• Filing date: Dec 18, 2014
• Grant date: Feb 23, 2016
• Expiry date: Dec 18, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.