Biocatalysts and methods for the synthesis of armodafinil
US9267159B2 · kind B2 · utility
9Cited by
15References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 7, 2011 |
| Grant date | Feb 23, 2016 |
| Priority date | — |
| Expiry date | Jun 30, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.