Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
US9271658B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 9, 2012 |
| Grant date | Mar 1, 2016 |
| Priority date | — |
| Expiry date | May 23, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T7/0012
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A non-invasive method for measuring blood flow in principal vessels of a heart of a subject is provided. The method includes illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow rate in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.