Patent · US Active

Method of inhibiting nonsense-mediated mRNA decay

US9271998B2 · kind B2 · utility

4Cited by

5References

17Claims

0Family size

Assignee

Rutgers, the State University of New Jersey · US

Inventors

Tsafi Pe'ery · Montclair, US
Michael B. Mathews · Montclair, US
Mainul Hoque · North Arlington, US
Hartmut Hanauske-Abel · Edgewater, US

Key dates

Filing date	Nov 18, 2013
Grant date	Mar 1, 2016
Priority date	—
Expiry date	Nov 18, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.