IFN-beta compositions, preparation methods and uses thereof
US9272020B2 · kind B2 · utility
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10Claims
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Assignee
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Key dates
| Filing date | May 16, 2012 |
| Grant date | Mar 1, 2016 |
| Priority date | — |
| Expiry date | Jun 27, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.