Patent · US Active

Compositions, comprising improved IL-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

US9272024B2 · kind B2 · utility

9Cited by

3References

21Claims

0Family size

Assignee

The Trustees of the University of Pennsylvania · US

Inventors

David B. Weiner · Yeadon, US
Matthew P. Morrow · Yeadon, US
Jian Yan · Wallingford, US

Key dates

Filing date	Dec 11, 2012
Grant date	Mar 1, 2016
Priority date	—
Expiry date	Dec 11, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2730/10171
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL-12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.