Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US9272043B2 · kind B2 · utility
11Cited by
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44Claims
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Key dates
| Filing date | Jun 2, 2014 |
| Grant date | Mar 1, 2016 |
| Priority date | — |
| Expiry date | Jun 2, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y113/12007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
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