PEGylated recombinant human growth hormone compounds

US9272048B2 · kind B2 · utility

Assignee

• Ascendis Pharma Growth Disorders Division A/S · DK

Inventors

• Harald Rau · Würzburg, DE
• Susanne Kinderman · Heidelberg, DE
• Torben Lebmann · Mannheim, DE
• Grethe Rasmussen · Copenhagen, DK
• Ulrich Hersel · Heidelberg, DE
• Thomas Wegge · Heidelberg, DE
• Kennett Sprogoe · Greve Strand, DK

Key dates

• Filing date: Apr 29, 2009
• Grant date: Mar 1, 2016
• Expiry date: May 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/61
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.