Patent · US Active

Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof

US9272978B2 · kind B2 · utility

7Cited by

1References

16Claims

0Family size

Assignee

WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · CN

Inventors

Wensheng Zhang · Sichuan, CN
Jun Yang · Oak Ridge, US
Jin Liu · Beijing, CN

Key dates

Filing date	Oct 13, 2010
Grant date	Mar 1, 2016
Priority date	—
Expiry date	Jan 13, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C69/675
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.