Method for preparing high-purity fesoterodine fumarate

US9272982B2 · kind B2 · utility

Assignee

• CHEMI S.P.A. · IT

Inventors

• Umberto Ciambecchini · Roma, IT
• Elio Ullucci · Latina, IT
• Stefano Turchetta · Roma, IT
• Maurizio Zenoni · Paullo, IT

Key dates

• Filing date: Jun 19, 2014
• Grant date: Mar 1, 2016
• Expiry date: Jun 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C219/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.