Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication

US9273067B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• B. Narasimhulu Naidu · Durham, US
• Michael A. Walker · Durham, US
• Margaret E. Sorenson · Swedesburg, US
• Manoj Patel · Berlin, US
• Zhizhen Barbara Zheng · Cheshire, US
• John F. Kadow · Wallingford, US
• Bin Zheng · Hangzhou City, CN
• Martin D. Eastgate · Titusville, US
• Ke Chen · Sichuan, CN
• Francisco Gonzalez-Bobes · New Brunswick, US

Key dates

• Filing date: Feb 11, 2015
• Grant date: Mar 1, 2016
• Expiry date: Feb 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/48
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.