Phosphorus derivatives as kinase inhibitors

US9273077B2 · kind B2 · utility

Assignee

• Ariad Pharmaceuticals, Inc. · US

Inventors

• Yihan Wang · 安丰镇, CN
• Wei-Sheng Huang · Cambridge, US
• Shuangying Liu · Wellesley, US
• William C. Shakespeare · Framingham, US
• R. Mathew Thomas · Sharon, US
• Jiwei Qi · Dedham, US
• Feng Li · Winchester, US
• Xiaotian Zhu · Newton, US
• Anna Kohlmann · Winchester, US
• David C. Dalgarno · Brookline, US
• Jan Antoinette C. Romero · Somerville, US
• Dong Zou · Concord, US

Key dates

• Filing date: Mar 15, 2013
• Grant date: Mar 1, 2016
• Expiry date: Mar 15, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/657172
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention features compounds of the general formula:in which the variable groups are as defined herein, and to their preparation and use as protein kinase inhibitors.