Patent · US Active

Targeted 2′-O-methylation of telomerase non-coding RNA

US9273294B2 · kind B2 · utility

3Cited by

1References

4Claims

0Family size

Assignee

University of Rochester · US

Inventors

Yi Yu · Pittsford, US
Chao-Hsiang Huang · Hengshan, TW

Key dates

Filing date	Jul 15, 2011
Grant date	Mar 1, 2016
Priority date	—
Expiry date	Jan 20, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/321
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Processes and C/D box small nucleolar RNAs (snoRNAs) for altering telomerase activity and altering telomerase length are described. The processes of the invention involve the use of C/D box snoRNAs for targeted 2′-O-methylation modification of nucleotides in a pseudoknot region of the telomerase RNA. Depending on their position, the 2′-O-methylation modifications can cause an increase in telomerase activity and subsequent telomere lengthening or a decrease in telomerase activity and subsequent telomere shortening.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.