Mouse models carrying a knock-out mutation of the QPCTL-gene

US9277737B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Hans-Ulrich Demuth · Halle (Saale), DE
• Anett Stephan · Halle (Saale), DE
• Birgit Koch
• Holger Cynis · Dohnsen, DE
• Stephan Schilling · Halle (Saale), DE
• Reinhard Sedlmeier · Munich, DE
• Sigrid Graubner · Munich, DE

Key dates

• Filing date: May 6, 2013
• Grant date: Mar 8, 2016
• Expiry date: May 6, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2267/0368
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A knock-out non-human animal, in particular a mouse, carrying a QPCTL knock-out mutation. Additionally, respective cells and cell lines and methods and compositions for evaluating agents that affect QPCTL, for use in compositions for the treatment of QPCTL-related diseases are disclosed.