HMGB1 binding nucleic acid molecule and applications thereof
US9278108B2 · kind B2 · utility
7Cited by
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13Claims
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Key dates
| Filing date | Jul 16, 2010 |
| Grant date | Mar 8, 2016 |
| Priority date | — |
| Expiry date | Aug 28, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10−7 or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.