Lipids and compositions for intracellular delivery of biologically active compounds

US9278130B2 · kind B2 · utility

Assignee

• AXOLABS GMBH · DE

Inventors

• Rainer Constien · Kulmbach, DE
• Anke Geick · Bayreuth, DE
• Philipp Hadwiger · Kulmbach, DE
• Torsten Haneke · Kulmbach, DE
• Ludger Markus Ickenstein · Kulmbach, DE
• Carla Alexandra Hernandez Prata · Kulmbach, DE
• Andrea Schuster · Bayreuth, DE
• Timo Weide · Kulmbach, DE

Key dates

• Filing date: Feb 12, 2014
• Grant date: Mar 8, 2016
• Expiry date: Feb 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.