Patent · US Active

Process for lowering the viscosity of highly concentrated protein solutions

US9278131B2 · kind B2 · utility

5Cited by

17References

30Claims

0Family size

Assignee

ADOCIA · FR

Inventors

Emmanuel DAUTY · Val-de-Reuil, FR
Thomas Ballet · Val-de-Reuil, FR
Remi Soula · Val-de-Reuil, FR

Key dates

Filing date	Aug 8, 2013
Grant date	Mar 8, 2016
Priority date	—
Expiry date	Jun 27, 2034

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K9/0019
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8.The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.