Patent · US Active

Aqueous methacetin solutions labelled with 13C having propylene glycol as a solubilizer

US9278145B2 · kind B2 · utility

1Cited by

3References

14Claims

0Family size

Assignees

FREIE UNIVERSITÄT BERLIN · DE
CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE

Inventors

Martin Stockmann · Berlin, DE
Björn Riecke · Schwielowsee, DE

Key dates

Filing date	Nov 25, 2014
Grant date	Mar 8, 2016
Priority date	—
Expiry date	Nov 25, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S436/90
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

An analysis method determines a functional parameter of an organ by measuring 13CO2 content in exhaled air of an individual to which a substrate has been administered. The reaction of the substrate in the body of the individual enriches the exhaled air with 13CO2. The maximum reaction rate of the substrate in the body is determined via a change of the measured 13CO2 content in the exhaled air using zero-order enzyme kinetics. An aqueous methacetin solution having a pH greater than 7.0 is used in the analysis method. A face mask separates the exhaled air from inhaled air. The face mask is configured such that inhaled and exhaled air flows essentially completely through the face mask. Exhalation and inhalation valves in the face mask allow a flow of inhaled and exhaled air through the face mask. A diagnostic method is used to determine the functional parameters of the organ.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.