Patent · US Active

Intermediates of neutral endopeptidase inhibitors and preparation method thereof

US9278908B2 · kind B2 · utility

0Cited by

2References

11Claims

0Family size

Assignee

Novartis AG · CH

Inventors

David Hook · Rheinfelden, CH
Jianguang Zhou · 林湖乡, CN
Yunzhong Li · 安丰镇, CN
Jie Ku · Suzhou, CN

Key dates

Filing date	Jun 15, 2015
Grant date	Mar 8, 2016
Priority date	—
Expiry date	Jun 15, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D207/38
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.