Patent · US Active

Synthesis of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

US9278919B1 · kind B1 · utility

1Cited by
0References
20Claims
0Family size

Inventor

Key dates

Filing dateMar 13, 2015
Grant dateMar 8, 2016
Priority date—
Expiry dateMar 13, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D239/545
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

A method for preparing BTK inhibitor CC-292 of formula 1, comprising: (1) contacting a compound of formula 2 with a compound of formula 3 to obtain a compound of formula 4; (2) contacting the compound of formula 4 with a compound of formula 5 to obtain a compound of formula 6; (3) contacting the compound of formula 6 with trifluoromethanesulfonic anhydride to obtain a compound of formula 7; and (4) contacting the compound of formula 7 with a compound of formula 8 to obtain the compound of formula 1,

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.