Patent · US Active

Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes

US9278920B2 · kind B2 · utility

0Cited by

4References

12Claims

0Family size

Assignee

NABRIVA THERAPEUTICS GMBH · AT

Inventors

Rosemarie Riedl · Wien, AT
Klaus Thirring · Wien, AT
Werner Heilmayer · Staprijk, AT

Key dates

Filing date	Aug 11, 2011
Grant date	Mar 8, 2016
Priority date	—
Expiry date	Aug 11, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2603/99
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds selected from the group of N-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C0-4)alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cycloheptylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclooctylsulfanyl)-acetyl]-mutilins, or 14-O-[(amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl]-mutilins, optionally in the form of a salt and/or a solvate, a pharmaceutical compositions comprising such compounds and their use as pharmaceuticals, e.g. for the treatment of microbial infections and for the treatment of acne, optionally in combination with other pharmaceutically active agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.