Pyrrolidine derivatives, pharmaceutical compositions and uses thereof

US9278954B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Niklas Heine · Eberhardzell, DE
• Martin Fleck · Warthausen, DE
• Bernd Nosse · Biberach an der Riß, DE
• Gerald Juergen Roth · Biberach, DE

Key dates

• Filing date: May 12, 2014
• Grant date: Mar 8, 2016
• Expiry date: May 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrrolidine derivatives which are inhibitors of acetyl-CoA carboxylase(s) and their use in the treatment of obesity and type-2 diabetes. An exemplary compound is 2-(4-(1-[5-Chloro-6-(2-hydroxy-2-methyl-propoxy)-pyrimidin-4-yl]-(R)-pyrrolidin-3-yloxy)-phenyl)-N-cyclopropyl-propionamide.