T cell receptor display
US9279122B2 · kind B2 · utility
3Cited by
0References
5Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 9, 2014 |
| Grant date | Mar 8, 2016 |
| Priority date | — |
| Expiry date | Apr 9, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.