Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis

US9279123B2 · kind B2 · utility

Assignee

• T2CURE GMBH · DE

Inventors

• Stefanie Dimmeler · Frankfurt am Main, DE
• Andreas M. Zeiher · Glückstadt, DE
• Angelika Bonauer · Frankfurt, DE
• Carmen Urbich · Goldkronach, DE

Key dates

• Filing date: Jul 31, 2014
• Grant date: Mar 8, 2016
• Expiry date: Jul 31, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.