Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
US9279806B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2014 |
| Grant date | Mar 8, 2016 |
| Priority date | — |
| Expiry date | Feb 4, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/62
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compounds that exhibit aggregation induced emission (AIE), and more particularly to water-soluble conjugated polyene compounds that exhibit aggregation induced emission. The conjugated polyene compounds can be used as bioprobes for DNA detection, G-quadruplex identification, and potassium-ion sensing. The polyenes also can be utilized as an external fluorescent marker to study conformational structures, to monitor folding processes of label-free oligonucleotides with G-rich strand sequences, and to visualize DNA bands in PAGE assay. The polyenes have applications in high-throughput anticancer drug screening and are useful for the development of efficient anti-cancer drugs. Furthermore, the present subject matter can also be used to monitor fibrillation of amyloid proteins and to facilitate the storage and delivery thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.