Fused pyrroledicarboxamides and their use as pharmaceuticals

US9284333B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Laurent Bialy · Frankfurt am Main, DE
• Katrin Lorenz · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE
• Klaus Steinmeyer · Frankfurt am Main, DE
• Gerhard Hessler · Hofheim, DE

Key dates

• Filing date: Feb 1, 2013
• Grant date: Mar 15, 2016
• Expiry date: Feb 1, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to fused pyrroledicarboxamides of the formula (I), in which R1 to R9, X, m and n are as defined in the claims. The compounds of the formula (I) are inhibitors of the acid-sensitive potassium channel TASK-1 and suitable for the treatment of TASK-1 channel-mediated diseases such as arrhythmias, in particular atrial arrhythmias like atrial fibrillation or atrial flutter, and respiratory disorders, in particular sleep-related respiratory disorders like sleep apnea, for example.