Monodisperse random coil proteins and bioconjugates thereof

US9284590B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Jennifer S. Lin · Palo Alto, US
• Annelise E. Barron · Palo Alto, US
• Jennifer Albrecht · Waverly, US
• Xiaoxiao Wang · Tangxia, CN

Key dates

• Filing date: Dec 15, 2011
• Grant date: Mar 15, 2016
• Expiry date: Aug 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/21
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure provides substantially monodisperse random coil polypeptides, vectors encoding the polypeptides, conjugates containing the polypeptides, methods for their preparation, and their uses in nucleic acid separations, DNA sequencing, and other applications requiring high monodispersity.