Urgency therapy with neuromodulation and C-afferent nerve desensitization
US9289607B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 16, 2011 |
| Grant date | Mar 22, 2016 |
| Priority date | — |
| Expiry date | Aug 7, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H20/17
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.