Electrophilic reagents for monohalomethylation, their preparation and their uses
US9290446B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Oct 27, 2011 |
| Grant date | Mar 22, 2016 |
| Priority date | — |
| Expiry date | Mar 29, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such reagents. Typical monohalomethyl groups transferred are FH2C—, CIH2C— and others. The reagents used for transferal of the groups are described by Formulae A-D: wherein: X=F, Cl, Br, I, sulfonate esters, phosphate esters or another leaving group; R11=tetrafluoroborates, inflates, halogen, perchlorate, sulfates, phosphates or carbonates The other variables are as defined in the claims.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.