Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme

US9290500B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Roushan Afroze · Lexington, US
• Indu T. Bharathan · Somerville, US
• Jeffrey P. Ciavarri · Reading, US
• Paul E. Fleming · Wellesley, US
• Jeffrey L. Gaulin · Epping, US
• Mario Girard · Quincy, US
• Steven P. Langston · North Andover, US
• Francois Soucy · Stoneham, US
• Tzu-Tshin Wong · Belmont, US
• Yingchun Ye · Belmont, US

Key dates

• Filing date: Feb 14, 2013
• Grant date: Mar 22, 2016
• Expiry date: Apr 22, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.