Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies

US9290573B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Feng Cong · Quincy, US
• Seth Ettenberg · Cambridge, US
• David Jenkins · Waltham, US
• Ming Lei · Princeton, US
• Andreas Loew · Somerville, US
• Karen Vincent · Arlington, US
• Li Zhou · Cambridge, US

Key dates

• Filing date: May 5, 2011
• Grant date: Mar 22, 2016
• Expiry date: Jun 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.