Microfluidic system having monolithic nanoplasmonic structures
US9291567B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Mar 12, 2012 |
| Grant date | Mar 22, 2016 |
| Priority date | — |
| Expiry date | May 15, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T137/8593
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A microfluidic system has a monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements for plasmonic response monitoring and a network of microchannels. Advantageously, low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques can be provided. A ratio of greater than 0.2 of the cross-sectional dimension and the spacing between the nano-scale elements is useful for plasmonic response monitoring. Producing such a system involves a master mold with the nano-scale elements etched into a hard substrate, and the network provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold. Features of the intended device can be transferred to a polymeric substrate using the stamp.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.