Patent · US Active

Cationic oil-in-water emulsions

US9295646B2 · kind B2 · utility

45Cited by

13References

32Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Luis Brito · Cambridge, US
Andrew Geall · Littleton, US
Derek O'Hagan · Winchester, US
Manmohan Singh · Cary, US

Key dates

Filing date	Sep 18, 2011
Grant date	Mar 29, 2016
Priority date	—
Expiry date	Sep 18, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.