Episomal reprogramming with chemicals
US9295697B2 · kind B2 · utility
5Cited by
2References
28Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 4, 2010 |
| Grant date | Mar 29, 2016 |
| Priority date | — |
| Expiry date | Jan 10, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells with cell signaling regulators are described. Furthermore, certain aspects of the invention provide novel compositions comprising induced pluripotent stem cells essentially free of exogenous retroviral vector elements in the presence of a medium comprising signaling inhibitors. In certain aspects, feeder-free episomal reprogramming methods may be provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.