Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
US9296699B2 · kind B2 · utility
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Key dates
| Filing date | Jun 8, 2012 |
| Grant date | Mar 29, 2016 |
| Priority date | — |
| Expiry date | Oct 11, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.