Patent · US Active

Method for preparing ALK inhibitor ceritinib

US9296721B1 · kind B1 · utility

1Cited by
0References
14Claims
0Family size

Inventor

Key dates

Filing dateFeb 13, 2015
Grant dateMar 29, 2016
Priority date—
Expiry dateFeb 13, 2035

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02P20/55
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Embodiment of present disclosure provides a method for preparing ceritinib of formula I, comprising: (1) contacting a compound of formula 12b with an amino protective group to obtain a compound of formula 3; (2) contacting the compound of formula 3 with a compound of formula 9a to obtain a compound of formula 5; and (3) subjecting the compound of formula 5 to a deprotection reaction to obtain the ceritinib of formula I. Then ceritinib may be effectively prepared.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.