(1-azinone)-substituted pyridoindoles

US9296743B2 · kind B2 · utility

Assignee

• ALBANY MOLECULAR RESEARCH, INC. · US

Inventors

• Peter R. Guzzo · Niskayuna, US
• Matthew David Surman · Albany, US
• Alan John Henderson · Sandwich, GB
• May Xiaowu Jiang · Guilderland, US
• Mark Hadden · Albany, US
• James Grabowski · East Greenbush, US
• Alexander Usyatinsky · Coralville, US

Key dates

• Filing date: Mar 24, 2014
• Grant date: Mar 29, 2016
• Expiry date: Mar 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D521/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I)wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.