Process for alkynylating 16-substituted-17-keto steroids
US9296780B2 · kind B2 · utility
9Cited by
1References
12Claims
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Key dates
| Filing date | Dec 19, 2012 |
| Grant date | Mar 29, 2016 |
| Priority date | — |
| Expiry date | Dec 19, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17β-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.