Serum amyloid P derivatives and their preparation and use
US9296800B2 · kind B2 · utility
7Cited by
31References
52Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 4, 2010 |
| Grant date | Mar 29, 2016 |
| Priority date | — |
| Expiry date | May 26, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.