Patent · US Active

Fibronectin-based binding molecules and uses thereof

US9296810B2 · kind B2 · utility

0Cited by
14References
1Claims
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Assignee

Inventors

Key dates

Filing dateMay 4, 2009
Grant dateMar 29, 2016
Priority date—
Expiry dateMay 23, 2032

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2333/78
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The invention provides fibronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecific Fn3-based binding molecules that bind to two or more targets simultaneously. The Fn3-based binding molecules of the invention can also be linked together to form multispecific Fn3-based binding molecules, and/or can be conjugated to a non-Fn3 moiety, such as, Human Serum Albumin (HSA), for improved half life and stability. The invention also provides methods for generating, screening and using Fn3-based binding molecules in a variety of therapeutic and diagnostic applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.