Compositions and methods of use for antibodies of Dickkopf-1

US9296813B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Janine Shulok · Newton, US
• Feng Cong · Quincy, US
• Mark C. Fishman · Newton, US
• Seth Ettenberg · Cambridge, US
• Michael Bardroff · Soest, DE
• Mariel Donzeau · Strasbourg, FR
• Stefanie Urlinger · Munich, DE

Key dates

• Filing date: Feb 12, 2014
• Grant date: Mar 29, 2016
• Expiry date: Nov 22, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.