Human monoclonal antibodies to O8E

US9296822B2 · kind B2 · utility

Assignee

• E.R. SQUIBB & SONS, L.L.C. · US

Inventors

• Alan J. Korman · Piedmont, US
• Mark J. Selby · San Francisco, US
• Li-Sheng Lu · Mountain View, US
• Alison Witte · Scotts Valley, US
• Haichun Huang · Fremont, US

Key dates

• Filing date: Nov 7, 2013
• Grant date: Mar 29, 2016
• Expiry date: Apr 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.