Local drug delivery devices and methods for treating cancer

US9301926B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The General Hospital Corporation · US

Inventors

• Laura Indolfi · Boston, US
• Elazer R. Edelman · Brookline, US
• Robert S. Langer · Newton, US
• Jeffrey W. Clark · Sharon, US
• David T. Ting · Dover, US
• Cristina Ferrone · Boston, US
• Matteo Ligorio · Boston, US

Key dates

• Filing date: Apr 10, 2014
• Grant date: Apr 5, 2016
• Expiry date: Apr 10, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2420/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.