NAMPT and rock inhibitors

US9302989B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Michael L. Curtin · Pleasant Prairie, US
• Bryan K. Sorensen · Antioch, US
• Howard R. Heyman · Deerfield, US
• Richard F. Clark · Mundelein, US
• Kevin R. Woller · Antioch, US
• Omar J. Shah · Lake Villa, US
• Michael R. Michaelides · Gurnee, US
• Chris Tse · Libertyville, US
• Anil Vasudevan · Union Grove, US
• Helmut Mack · Ludwigshafen, DE
• Todd M. Hansen · Grayslake, US
• Ramzi F. Sweis · Vernon Hills, US
• Marina Pliushchev · Vernon Hills, US

Key dates

• Filing date: Nov 11, 2011
• Grant date: Apr 5, 2016
• Expiry date: Nov 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.