2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

US9303017B2 · kind B2 · utility

Assignees

• Georgetown University · US
• Duke University · US

Inventors

• Yingxian Xiao · Potomac, US
• Kenneth J. Kellar · Bethesda, US
• Milton L. Brown · Brookeville, US
• Mikell Paige · Fairfax, US
• Yong-Jun Liu · Oakville, CA
• Edward D. Levin · Chapel Hill, US
• Amir H. Rezvani · Chapel Hill, US

Key dates

• Filing date: Nov 9, 2012
• Grant date: Apr 5, 2016
• Expiry date: Nov 9, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.