Process for the preparation of heterocyclic ester derivatives

US9303046B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Jean-Pierre Andre Marc Bongartz · Turnhout, BE
• Alfred Elisabeth Stappers · Oud-Turnhout, BE
• Christopher A. Teleha · Fort Washington, US
• Koen Johan Herman Weerts · Vosselaar, BE
• Kenneth Wilson · Puntarenas, CR

Key dates

• Filing date: Aug 5, 2013
• Grant date: Apr 5, 2016
• Expiry date: Aug 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula Iwherein A1, SEM, and W1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.