Patent · US Active

Phosphonate ester derivatives and methods of synthesis thereof

US9303051B2 · kind B2 · utility

5Cited by

15References

9Claims

0Family size

Assignee

CHIMERIX, INC. · US

Inventors

Roy W. Ware · Raleigh, US
Merrick R. Almond · Apex, US
Bernhard M. Lampert · Roxboro, US

Key dates

Filing date	Jul 24, 2015
Grant date	Apr 5, 2016
Priority date	—
Expiry date	Jul 24, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.