D-amino acid derivative-modified peptidoglycan and methods of use thereof

US9303068B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Carolyn R. Bertozzi · Berkeley, US
• Mary Sloan Siegrist Palmore · Berkeley, US
• John C. Jewett · Tucson, US
• Chelsea G. Gordon · Berkeley, US
• Peyton Shieh · Cambridge, US

Key dates

• Filing date: Nov 27, 2013
• Grant date: Apr 5, 2016
• Expiry date: Nov 27, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/195
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.