Nucleic acid molecules and methods for exchanging exon(s) by transsplicing
US9303078B2 · kind B2 · utility
2Cited by
3References
22Claims
0Family size
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Key dates
| Filing date | Oct 8, 2010 |
| Grant date | Apr 5, 2016 |
| Priority date | — |
| Expiry date | Jan 25, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provided methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (Chimeric RNA).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.