Means and methods for assessing increased peroxisomal proliferation

US9304136B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Bennard van Ravenzwaay · Altrip, DE
• Werner Mellert · Haßloch, DE
• Eric Fabian · Ludwigshafen, DE
• Volker Strauss · Bad Dürkheim, DE
• Tilmann B. Walk · Kleinmachnow, DE
• Ralf Looser · Berlin, DE
• Edgar Leibold · Bischofswerda, DE
• Hennicke Kamp · Bischheim, DE
• Georgia Coelho Palermo Cunha · São Paulo, BR
• Michael Manfred Herold · Berlin, DE
• Jan C. Wiemer · Berlin, DE
• Alexandre Prokoudine · Berlin, DE

Key dates

• Filing date: Jan 10, 2014
• Grant date: Apr 5, 2016
• Expiry date: Jan 10, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection including characteristic values of at least five metabolites, a data storage medium including data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.